Abstract
We review integrated optical sensors for functional brain imaging, localized index-of-refraction sensing as part of a lab-on-a-chip, and in vivo continuous monitoring of tumor and cancer stem cells. We present semiconductor-based sensors and imaging systems for these applications. Measured intrinsic optical signals and tissue optics simulations indicate the need for high dynamic range and low dark-current neural sensors. Simulated and measured reflectance spectra from our guided resonance filter demonstrate the capability for index-of-refraction sensing on cellular scales, compatible with integrated biosensors. Finally, we characterized a thermally evaporated emission filter that can be used to improve sensitivity for in vivo fluorescence sensing.
© 2007 Optical Society of America
Full Article | PDF ArticleMore Like This
Elizabeth A. Munro, Hart Levy, Dene Ringuette, Thomas D. O’Sullivan, and Ofer Levi
Opt. Express 19(11) 10747-10761 (2011)
Thomas O’Sullivan, Elizabeth A. Munro, Natesh Parashurama, Christopher Conca, Sanjiv S. Gambhir, James S. Harris, and Ofer Levi
Opt. Express 18(12) 12513-12525 (2010)
Steven C. Gebhart, Reid C. Thompson, and Anita Mahadevan-Jansen
Appl. Opt. 46(10) 1896-1910 (2007)