Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Time-resolved optical tomography using short-pulse laser for tumor detection

Not Accessible

Your library or personal account may give you access

Abstract

Our objective is to perform a comprehensive experimental and numerical analysis of the short-pulse laser interaction with a tissue medium with the goal of tumor–cancer diagnostics. For a short-pulse laser source, the shape of the output signal is a function of the optical properties of the medium, and hence the scattered temporal optical signal helps in understanding the medium characteristics. Initially experiments are performed on tissue phantoms embedded with inhomogeneities to optimize the time-resolved optical detection scheme. Both the temporal and the spatial profiles of the scattered reflected and transmitted optical signals are compared with the numerical modeling results obtained by solving the transient radiative transport equation using the discrete ordinates technique. Next experiments are performed on in vitro rat tissue samples to characterize the interaction of light with skin layers and to validate the time-varying optical signatures with the numerical model. The numerical modeling results and the experimental measurements are in excellent agreement for the different parameters studied. The final step is to perform in vivo imaging of anesthetized rats with tumor-promoting agents injected inside skin tissues and of an anesthetized mouse with mammary tumors to demonstrate the feasibility of the technique for detecting tumors in an animal model.

© 2006 Optical Society of America

Full Article  |  PDF Article
More Like This
Experimental and numerical analysis of short-pulse laser interaction with tissue phantoms containing inhomogeneities

Champak Das, Ashish Trivedi, Kunal Mitra, and Tuan Vo-Dinh
Appl. Opt. 42(25) 5173-5180 (2003)

Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model

Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning, Bruce J. Tromberg, Gultekin Gulsen, Hon Yu, Jun Wang, and Orhan Nalcioglu
Appl. Opt. 42(16) 2951-2959 (2003)

Analysis of short-pulse laser photon transport through tissues for optical tomography

Mohamed Sakami, Kunal Mitra, and Tuan Vo-Dinh
Opt. Lett. 27(5) 336-338 (2002)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (17)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (1)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved